CHROMIUM GTF DOSAGE FOR DIABETES FREE

During diabetes, persistent high concentrations of blood glucose increase the production of oxygen free radicals – OFRs.

Oxidative stress and non enzymatic glycation play a major role in the pathogenesis of diabetes mellitus. The mechanism of action of GTF along insulin signaling pathway was also studied.Ĥ. We also examined GTF effects on the cellular level and found high insulin mimetic and insulin potentiating activity for GTF. We examined GTF effects in animal models for both types of diabetes, and found high and rapid anti diabetic activity. Our laboratory succeeded in extraction and partial purification of an active and stable GTF preparation from brewer’s yeast. ĭespite the high anti diabetic activity of this natural compound, GTF has not been fully characterized or identified, mainly due to the instability of the purified fractions. An increase in glucose incorporation into glycogen in rat hepatocytes was also found for GTF preparations. In vitro studies with GTF showed remarkable increase in glucose transport into adipocytes, and cardiomyocytes. GTF reversed the impaired glucose tolerance of both diabetic rats and diabetic patients. The Glucose Tolerance Factor (GTF) is a dietary agent first extracted from Brewer’s yeast. Although some of them have been studied for their anti diabetic effects, the knowledge on their efficacy and mechanism of action is very limited. A research aimed at revealing new natural sources to treat diabetes is of high importance.Ī variety of traditional anti diabetic plants are known in the folk medicine. During the recent years many investigators have shown that natural products are a potential source for new drug candidates for many diseases in general, and diabetes in particular. Materials that mimic insulin action or augment the effect of residual endogenous insulin are likely to be beneficial for both type 1 and 2 diabetic patients. An intense research has been conducted to identify new therapeutic targets and pharmacologic compounds that might correct the impaired glucose tolerance. As a result of the global epidemic of diabetes, the need for new diabetes therapies is expected to grow dramatically during the next decade. The medications currently in use are limited in their potency, have many side effects, and cannot be tolerated by many patients. Diabetes is the world’s most common metabolic disease and one of the leading causes of morbidity and mortality.

Chromium gtf dosage for diabetes